Can we truly give up all desires?
Perhaps not.
But can we give up one desire for another?
I feel like buying that cool looking $1200 new iPhone, but then seeing the $3500 Vision Pro makes my heart skip a beat (insane price and awesomeness both!).
So the interim solution is probably in trading desires upwards. Go for something better, and replace the lower.
Keep doing this, and we’ll realize that the only desire that truly and comprehensively fills the heart is the desire for God and the Self.
That’s also when we’ll accept that we already have everything that truly matters. What good is a desire for the one who has it all?